Follow your vet's recommendations about flea meds.
Be sure to ask your veterinarian to be sure it will be safe for your dog before you use any flea and tick products in combination, such as using two of more of the following together--Frontline, Advantage, a flea collar, flea shampoo, flea powder in dog beds, flea spraying the yard, flea shampooing the carpets, and flea bombing the house.